It’s Topic Tuesday!
- Sathyap Pallapothula
- Jun 16
- 2 min read
Hello Aortic Hope family! I hope that you’re having an amazing Tuesday so far! I’m sure that we all know when it comes to protecting your aorta and managing long-term cardiovascular health, blood pressure control is key. In this effort, two types of medications are often used: Angiotensin-Converting Enzyme (ACE) inhibitors and Angiotensin II Receptor Blockers (ARBs). But what exactly do these medications do? And why are they often recommended for people with aortic disease or those at risk?
What Are ACE-Is and ARBs?
Both of these medications work on the body’s renin-angiotensin system, which help regulate blood pressure:
ACE inhibitors (like enalapril or ramipril) block the enzyme angiotensin converting enzyme (ACE) which causes blood vessels to narrow. By stopping this, they help vessels stay relaxed, which lowers blood pressure.
ARBs (like losartan or valsartan) block the hormone angiotensin II from binding to its receptors, causing the blood vessels to relax and lower blood pressure.
In short, both medication types help lower blood pressure and damage to the aortic walls along with heart muscles.
Why Are These Medications Important for Aortic Health?
The aorta can be vulnerable to damage if blood pressure is consistently high. This is especially true for people with connective tissue disorders (like Marfan or Loeys-Dietz syndrome), or with a history of aortic enlargement or dissection.
ACE-Is and ARBs are commonly prescribed because they:
Help lower and stabilize blood pressure
Reduce stress on the aortic wall
May slow the progression of aortic dilation/aneurysms in some conditions
In particular, ARBs like losartan have been studied for their potential protective effects in patients with genetic aortic conditions—though both classes are valuable tools in aortic care.
What About Side Effects?
Both ACE-Is and ARBs are generally well tolerated, but side effects can occur:
ACE-Is may cause a dry cough, dizziness, and excess potassium levels in blood
ARBs tend to cause fewer side effects, but can still lead to dizziness, headache, and fatigue
It is crucial to understand these side effects and ask your physician about what medications might be the best fit for you!
Summary
ACE inhibitors and ARBs are more than just blood pressure medications—they’re important tools in helping protect the aorta from long-term stress and damage. If you’re taking one of these medications, or considering them as part of your care plan, it’s worth understanding how they work and why they’re often recommended in aortic disease management.
As always, it was a pleasure speaking with you today, and I can’t wait to see you again onour journey to living a heart healthy lifestyle!
Think Aorta,
Sathya Pallapothula
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